The hyaluronic acid promotes the healing process and helps to protect the newly formed tissue through its moisturising properties, while the collagenase assists in preparing the wound bed.
HYALO4® Start is a fluid ointment containing bacterial collagenase (from a non-pathogenic strain of Vibrio Alginolyticus) and hyaluronic acid for topical application. Hyaluronic acid promotes the healing process and protects the newly formed tissue thanks to its moisturizing action, while collagenase helps prepare the wound bed.
HYALO4® Start is indicated for local treatment of chronic wounds (bedsores, vascular leg ulcers, diabetic ulcers). In particular, it helps promote the best moisture environment, preparing the wound bed which helps the natural healing process.
Mechanism of action
The Vibrio Alginolyticus collagenase degrades type 1 collagen, acting on the triple chain by cleaving the Y-Gly bond in a –Pro-Y-Gly- type sequence. Pro-Y is more frequently a neutral amino acid. Hya- luronic acid protects and enables the migration of the fibroblasts and endothelial cells in the natural reepithelialisation process.
Hyaluronic acid alters the inflammatory phase, because it prevents the oxidising substances from interacting with the regenerating tissues, mediating the negative feed- back, and consequently the fibrosis is reduced in the remodelling phase.